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8Spheres微球联合碘油TACE治疗原发性肝癌的疗效及安全性.doc

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8Spheres微球联合碘油TACE治疗原发性肝癌的疗效及安全性.doc
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8Spheres微球联合碘油 TACE治疗原发 性肝癌的疗效及安全性 吴宝林 周军 凌公豪 Anu John 龙清云 武汉大学中南医院医学影像科 摘 要: 目的:探讨 8Spheres 适形栓塞微球联合碘油肝动脉化疗栓塞 (TACE) 治疗原发 性肝癌的近期疗效及安全性。方法:收集我院原发性肝癌患者共 64例。其中试验 组 (8Spheres 栓塞微球+碘油栓塞) 32例, 对照组 (单纯碘油栓塞) 32 例。比 较两组患者介入治疗前及治疗后 1周、1个月肝功能指标及甲胎蛋白 (AFP) 的 变化。术后3个月、6 个月评价两组患者肿瘤局部反应。同时比较两组患者术后 并发症发生情况。结果:患者基线临床特征无统计学差异 (均P>0.05) 。术后1 个月两组患者肝功能均改善, 但试验组肝功能指标 ALT、 AST和TBiL 明显优于对 照组 (均 P0.05) 。结论:与单纯碘油TACE相比, 8Spheres栓塞微球联合碘油 TACE 对治疗原发性肝癌近期疗效显著, 安全性较高, 值得临床推广。 其远期临床疗效 及生存获益有待进一步随访研究。 关键词: 肝癌; 肝动脉化疗栓塞; 疗效; 安全性; 8Spheres 栓塞微球; 作者简介:吴宝林, 男, 1990-, 医学硕士生, 主要从事肿瘤介入治疗方面的研 究, 15071498043@163.com 作者简介:龙清云, 男, 1968-, 医学博士, 主任医师, 主要从事肿瘤介入治疗 方面的研究, longqy2005@sina.com Efficacy and Safety Analysis of 8Spheres Microspheres Combined with Lipiodol TACE in the Treatment of Hepatocellular Carcinoma WU Baolin ZHOU Jun LING Gonghao Anu John LONG Qingyun Dept.of Radiology, Zhongnan Hospital of Wuhan University; Abstract: Objective:To investigate the short-term efficacy and safety of transarterial chemoembolization (TACE) with 8 Spheres shape-adapted embolic microspheres combined with lipiodol in the treatment of hepatocellular carcinoma (HCC) .Methods:A total of 64 patients with HCC were collected and divided into 32 cases of experimental group (8 Spheres microspheres+lipiodol) and32 cases of control group (lipiodol) .The liver function tests and AFP levels were compared between the two groups before interventional treatment, one week later, and one month later, respectively.The local tumor response of the two groups were evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) at the end of 3 and 6 months after treatment.At the same time, complications occurred after treatment were compared between the two groups.Results:There was no significant difference in baseline characteristics (P>0.05) .Liver function improved in both of the two groups after one month of treatment.However, theindexes of alanine aminotransferase
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