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橄榄苦甙对卵巢辐射损伤的防治效果.doc

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橄榄苦甙对卵巢辐射损伤的防治效果.doc
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( ) 32 SD 4 , , + 12 12 , + , 5 Gy X 1 7d (AMH) IL-1 IL-6 TNF- , , AMH (P0.05) 1 2.3 AMH AMH , AMH , , AMH (P>0.05) ; , AMH (P0.05) , (P0.05) 1 1 IL-1 IL-6 TNF- 2.5 7 d , ; 3/8 , ; + 2.6 , , ; , , ; , ; + , , 3 (P>0.05) (P0.05) ; + , , (P<0.05) 2 3 HE 2 3 3.1 , AMH [9] , AMH , , 2~8 mm AMH[10-11] , AMH [12] , , 0.1% , AMH, , AMH , [13] , , , 3.2 Pesty [14] (0.5 1 3 6 Gy) 6 , Said [3] 3.2 Gy 23 d SD , , 6~8 Balb/c 7.2 Gy , , , , [15] , , 0.2 Gy , , ; [16] , 5 Gy , AMH (P<0.05) ;3/8 ; , , , , , , , , 3.3 [3] DNA [16] IL-1 IL-6 IL-10 TNF- , [17-19] Das [20] , NF-k B , COX-2 , IL-6 TNF- , IL-1 IL-6 [21] , IL-1 IL-6 TNF- , IL-1 IL-6 TNF- IL-1 TNF- , TNF- , , , IL-1 , ; IL-1 6 8 TNF- , IL-1 IL-6 TNF- , + IL-1 IL-6 TNF- , , + AMH ; ; , , , [22] , , , , , IL-1 IL-6 TNF- , , [1] - oleuropein-enriched olive leaf extract in spontaneously hypertensive rats[J].Food funct, 2016, 7 (1) :584-593. [2]Ogun M, Ozcan A, Karaman M, et al.Oleuropein ameliorates arsenic induced oxidative stress in mice[J].J Trace Elem Med Biol, 2016, 36:1-6.doi:10.1016/j.jtemb.2016.03.006. [3]Said RS, Badr AM, Nada AS, et al.Sodium selenite treatment restores long-lasting ovarian damage induced by irradiation in rats:impact on oxidative stress and apoptosis[J].Repro toxicol, 2014, 43 (1) :85-93. [4]Yan CM, Chai EQ, Cai HY, et al.Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol3-kinase/protein kinase B pathway in Hep G2 human hepatoma cell line[J].Mol Med Rep, 2015, 11 (6) :4617-4624. [5]Secme M, Eroglu C, Dodurga Y, et al.Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells[J].Gene, 2016, 585 (1) :93-99. [6]Sioulas VD, Jorge S, Chern JY, et al.Robotically assisted laparoscopic ovarian transposition in women with lower gastrointestinal cancer undergoing pelvic radiotherapy[J].Ann Surg Oncol, 2016, 24 (10) :1-6. [7]Cora MC, Kooistra L, Travlos G.Vaginal cytology of the laboratory rat and mouse review and criteria for the staging of the estrous cycle using stained vaginal smears.[J].Toxicol Pathol, 2015, 43 (6) :776-793. [8]Erbas O, Akman L, Yavasoglu A, et al.Oxytocin improves follicular reserve in a cisplatin-induced gonadotoxicity model in rats[J].Biomed Res Int, 2014:703691.doi:10.1155/2014/703691. [9]Lunding SA, Aksglaede L, Anderson RA, et al.AMH as predictor of premature ovarian insufficiency:a longitudinal study of 120turner syndrome patients[J].J Clin Endocrinol Metab, 2015, 100 (7) :E1030-E1038.doi:10.1210/jc.2015-1621. [10]Jeppesen JV, Anderson RA, Kelsey TW, et al.Which follicles make the most anti-Mullerian hormone in humans?Evidence for an abrupt decline in AMH production at the time of follicle selection[J].Mol Hum Reprod, 2013, 19 (8) :519-527. [11]Broer SL, Mol B, Dolleman M, et al.The role of anti-Mullerian hormone assessment in assisted reproductive technology outcome[J].Curr Opin Obstet Gynecol, 2010, 22 (3) :193-201. [12]Van Disseldorp J, Lambalk CB, Kwee J, et al.Comparison of inter-and intra-cycle variability of anti-Mullerian hormone and antral follicle counts[J].Hum Reprod, 2010, 25 (1) :221-227. [13] -630. [14]Pesty A, Doussau M, Lahaye JB, et al.Whole-body or isolated ovary (60) Co irradiation:effects on in vivo and in vitro folliculogenesis and oocyte maturation[J].Reprod Toxicol, 2010, 29 (1) :93-98. [15]Sapmaz-Metin M, Kanter M, Uzal C.The role of ionizing radiaton on ovulation rate and oocyte morphology in mouse[J].Acta Biol Hung, 2014, 65 (1) :27-37. [16]Flegal M, Blimkie MS, Wyatt H, et al.Measuring DNA damage and repair in mouse splenocytes afterchronic in vivo exposure to very low doses of beta-and gamma-radiation[J].J Vis Exp, 2015, 101:e52912.doi:10.3791/52912. [17]Lu J, Wang C, Cao X, et al.Effect of zhuyeshigao granule on tumor necrosis factor-alpha and interleukins serum protein levels in rats with radiation esophagitis[J].J Tradit Chin Med, 2014, 34 (3) :338-341. [18]Chen H, Xiang H, Wu B, et al.Manganese superoxide dismutase gene modified mesenchymal stem cells attenuates acute radiationinduced lung injury[J].Hum Gene Ther, 2016, 106:1-24. [19]Pourkhodadad S, Alirezaei M, Moghaddasi M, et al.Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats[J].J Neurol Sci, 2016, 66 (5) :397-405. [20]Das U, Manna K, Sinha M, et al.Role of ferulic acid in the amelioration of ionizing radiation induced inflammation:a murine model[J].PLo S One, 2014, 9 (6) :e97599.doi:10.1371/journal.pone.0097599.e Collection 2014. [21]Ryu SJ, Choi HS, Yoon KY, et al.Oleuropein suppresses LPSinduced inflammatory responses in RAW 264.7 cell and zebrafish[J].J Agric Food Chem, 2015, 63 (7) :2098-2105. [22]Said RS, Nada AS, El-Demerdash E.Sodium selenite improves folliculogenesis in radiation-induced oarian failure:a mechanistic approach[J].PLo S One, 2012, 7 (12) :e50928.doi:10.1371/journal.pone.0050928.
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