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药学本科毕业论文 化合物A联合 化合物 B对人肝癌HepG2细胞作用机制研究.doc

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药学本科毕业论文 化合物A联合 化合物 B对人肝癌HepG2细胞作用机制研究.doc
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沈 阳 药 科 大 学本 科 毕 业 论 文论文题目:化合物 A 联合 化合物 B 对人肝癌 HepG2 细胞作用机制研究起止时间:2014 年 10 月 26 日—2015 年 6 月 20 日姓名学号:学院专业: 年级班级: 指导教师:XXX 副教授实习单位:XXX 大学生命科学与生物制药学院药理系2目 录中文摘要······································································1 英文摘要······································································2第 1 章 绪论··································································31.1 细胞凋亡·····························································31.2 立题依据·····························································5第 2 章 实验部分······························································62.1 实验材料·····························································62.2 实验方法·····························································72.3 实验结果····························································12第 3 章 结论与讨论···························································173.1 结沈阳药科大学本科毕业论文 目录3论································································173.2 讨论································································18参考文献·····································································21 致谢·········································································23摘 要原发性肝癌是世界常见的恶性肿瘤之一,也是我国的高发恶性肿瘤,由于不易被早期诊断,进展迅速,术后容易复发、转移,因此预后较差。目前肝癌仍以外科手术为公认首选和主要的治疗手段,但由于很多肝癌患者确诊时已是中晚期,失去了手术治疗的机会并于诊断后 1 年内死亡,手术切除率30%,术后总体 5 年生存率仅 30%~40%。对于可手术的肝癌患者,术后复发、转移是影响治疗效果及预后的主要因素,对于不能手术的中晚期肝癌患者尚缺乏有效的治疗方法。传统的化疗、放疗对肝癌疗效欠佳,目前仍缺乏行之有效的化学预防和治疗靶位 [1]。因而本课题是对化合物 A 联合化合物 B 对人肝癌 HepG2 细胞作用机制研究。本实验首先用 MTT 法分别测得不同浓度的 A 和 B 单独处理 HepG2 细胞及不同浓度的沈阳药科大学本科毕业论文 摘要1A 和 B 联合用药处理 HepG2 细胞死亡的影响。结果表明不同浓度的 A 和 B 单独处理 HepG2细胞,增值抑制程度表现为时间剂量依赖效应,并且在 A 6μmol/L 联合 B 100μmol/L 协同作用最为显著。流式细胞仪检测细胞凋亡率显示,联合用药组凋亡率升高更为明显。Western Blot 法检测蛋白显示,促凋亡相关蛋白 Bax、FADD 增加,抗凋亡蛋白 Bcl-2 表达减少。关键词 联合用药,细胞凋亡,作用机制AbstractHepatocellular carcinoma (HCC) is the most common cancer in the world and an increased malignant illness in our country. Because of its aggres
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