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阿扎胞苷治疗急性髓系白血病疗效探讨.pdf

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阿扎胞苷治疗急性髓系白血病疗效探讨.pdf
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· “5ùî·­=Í $Ÿ Ý“âÓh r)崔晶1 王景文1 刘复强1[K1] “¥:) €JÄ0þÍ $Ÿ Ý“âÓh¥ r。ZE:3 è$Ÿ Ý“âÓhÑ€‹¨­=Í ,4 ¹100mg/d, ÄñÛ ù5~ 7 d, 3~ 6ñÛ ù,4³‹¨ -ªÓÈ?# Ý%пM,iS©8Ñ、É /ÿ ?©。²T: è1 ™ ä8žÈÑ€ržÓÈ?# Ý`› †Ï³,K*Q‹ HW¹55d,Ñ€‚ ÖÓlð {ÿ,KQ‹¹Ólð9 ”, Q ^£“# ì“; è2ÇÓlð9 ”ržžÈ; è3ír,%hÉZ。¨0VñÏÃn üAý¬Q‹。² ‚: €JÄ0þ¿ º M、‚ ? 0 sÈ?Ä € €M± H¥Ñ€ V ? ^BÕµr、®ý¥Í  m 。[1oM] âÓh, Ý“,$Ÿ; €JÄ;­=[Ïms Ë|] R733.71 [ÓDS½ ’] A [ÓcI|] 1004-2806(2010)07-0388-03Evaluationofeffectivityofazacytidine inacutemyeloid leukemiaCUI J ing WANG J ingwen LIU Fuqiang(Department of Hematology, Beijing Tongren Hospital, Capital Medical University , Beijing,100730, China)Abstract Objective:Three patients with acute myeloid leukemia(AML)depending transfusion were treatedwith azacytidine of 3~ 6 cyclesinorder to evaluate the effectsof hypomethylating in treatment of AML.Method:Three patients withacutemyeloidleukemia(AML)were treatedwith azacytidine for3~ 6cyclesinorder to evalu-ate theeffects of hypomethylating agent in the treatment of AML.The hematologic and bone marrow changeswere observed during the treatment of azacytidine.Result:No.1 patient with normal karyotype achieved completeremission of hematology andbone marrow .She was independent of platelet transfusion at the 55th day after thetreatment of azacytidine.The earliest response was the increase of platelet, then red blood cellsand neutrophils.No.2patient achievedonly the recovery of platelet counts, but No.3 patient hadno response.Conclusion:Azacyti-dine may be a low toxic andeffective choice for those patients with AML who can not tolerate the chemotherapyandhave lost the chance of transplantation.Keywords leukemia, myeloid, acute;azacytidine;hypomethylatingÍ40 M¥ m ï P$Ÿ Ý“âÓh(AML) rµ  üA¥¿4,ŒYV ó†Ä ÉB„4Ú r¥
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